منابع مشابه
Grey zone between narcolepsy type 1 and type 2.
Dear Editor, The third International Classification of Sleep Disorders (ICSD-3) defines narcolepsy as patients with periods of sleep attacks or excessive daytime sleepiness. Neurophysiology tests with unremarkable polysomnography and positive Multiple Sleep Latency Test scores establish the diagnosis of narcolepsy1. The difficulties in the differential diagnosis include secondary causes of exce...
متن کاملMonozygotic twins discordant for narcolepsy type 1 and multiple sclerosis
Narcolepsy type 1 (NC1) is a neurologic sleep disorder caused by the loss of hypothalamic neurons that produce the sleep–wake regulating neuropeptides, the hypocretins (orexins). The pathogenesis is believed to be mainly autoimmune, based on the observation of a 95% to 100% association with the HLA-DQB1*06:02 allele, and on the recent strong indication of antigen presentation to T cells as cent...
متن کاملImmunohistochemical screening for antibodies in recent onset type 1 narcolepsy and after H1N1 vaccination.
Narcolepsy type 1 patients typically have undetectable hypocretin-1 levels in the cerebrospinal fluid (CSF), as a result of a selective loss of the hypocretin containing neurons in the hypothalamus. An autoimmune attack targeting hypothalamic hypocretin (orexin) neurons is hypothesised. So far, no direct evidence for an autoimmune attack was found. One of the major limitations of previous studi...
متن کاملCD4+ T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1
Introduction Narcolepsy type 1 is accompanied by a selective loss of orexin/hypocretin (hcrt) neurons in the lateral hypothalamus caused by yet unknown mechanisms. Epidemiologic and genetic associations strongly suggest an immune-mediated pathogenesis of the disease. Methods We compared specific T-cell reactivity to orexin/hcrt peptides in peripheral blood mononuclear cells of narcolepsy type...
متن کاملNarcolepsy type 1 and hypersomnia associated with a psychiatric disorder show different slow wave activity dynamics.
The aim of the study was to compare electrophysiological parameters of night sleep in narcolepsy type 1 and hypersomnia associated with a psychiatric disorder. Fortyfour patients: 15 with narcolepsy type 1, 14 with hypersomnia associated with a psychiatric disorder and 15 age- and sex-matched controls participated in the study. The study subjects filled in the Athens Insomnia Scale (AIS) and th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Lung India
سال: 2019
ISSN: 0970-2113
DOI: 10.4103/lungindia.lungindia_389_15